Mitomycin C: Mechanistic Precision and Translational Powe...

2025-10-21

Mitomycin C, a gold-standard antitumor antibiotic and DNA synthesis inhibitor, is transforming apoptosis signaling research and translational oncology. This thought-leadership article provides mechanistic insight into its role as a TRAIL-induced apoptosis potentiator, strategic guidance for experimental design, and a forward-looking vision for its integration into next-generation combination therapies. By contextualizing Mitomycin C within the evolving landscape of DNA-damaging agents and referencing recent antiviral genome-editing breakthroughs, this article charts new territory for innovative translational researchers.